To start setting up your Trezor device, visit trezor.io/start. Begin by connecting your Trezor to your computer using the USB cable provided. Follow the on-screen prompts to initialize your device and create a secure PIN. Next, you'll be guided to write down your recovery seed—a crucial backup of your wallet. Make sure to keep this seed phrase safe and offline. Once your device is set up, you can install the Trezor Bridge or Trezor Suite software to manage your cryptocurrencies securely. Trezor.io/start provides detailed instructions tailored to ensure your assets are protected right from the setup process.